đ Science and Medical Approaches to Enhance Longevity
1. Lifestyle interventions such as exercise, balanced nutrition, calorie restriction, adequate sleep, avoiding smoking and excessive alcohol use have been shown to improve health and potentially increase lifespan[7][10].
2. Pharmacological therapies using drugs like rapamycin, metformin, spermidine, and NAD+ precursor supplements have shown anti-aging effects in animal experiments, but need further validation in humans[9].
3. Cellular approaches involve targeting senescent cells to reduce inflammation[4], using stem cell therapies[1], and regenerative medicine to repair age-related damage[3].
4. Genetic interventions aim to identify longevity-associated genes that could be targeted by drugs[4], utilize gene therapy[3], and potentially modify the human genome[2].
5. Studying long-lived populations like centenarians to understand the physiological characteristics and gene variants linked to their extreme longevity[4][6].
6. A multi-disciplinary approach spanning biology, genetics, social sciences, physical sciences and engineering to expand the horizons of aging research beyond the traditional areas[5].
The overarching goal is to delay the biological processes of aging in order to prevent age-related diseases and extend the healthy lifespan[5][8]. While significant progress has been made in animal models, translating these interventions to humans remains an ongoing challenge that will require further research and innovation in the field of geroscience[3][6].